mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. it has shown a better efficacy than other drugs in this group. for assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. in this study mutagenic effect of mebudipine was evaluated using ames assay that could assess the mutageni...

Introduction: Increasing pressure on available funds in health care section especially hospitals, enhances the need of analyzing different strategies in economic terms. One of the solutions for the optimal use of financial resources and potentials in hospitals and health care centers is using elements of the marketing mix. In this way we could make the best use of the resources...

Metabolic activation of benzene by rat liver microsomes and a reduced nicotinamide adenine dinucleotide phosphate-generating system (S-9 mix) induced sister chromatid exchanges (SCEs) and cell division delays in cultured human lymphocytes. There were optimal concentrations of S-9 mix for the conversion of benzene into the active metabolites that exerted these cytotoxic effects. Reduced glutathi...

Metabolic activation of benzene by rat liver microsomes and a reduced nicotinamide adenine dinucleotide phosphate-gen erating system (S-9 mix) induced sister chromatid exchanges (SCEs) and cell division delays in cultured human lymphocytes. There were optimal concentrations of S-9 mix for the conver sion of benzene into the active metabolites that exerted these cytotoxic effects. Reduced glutat...

OBJECTIVE Performance measures are tools for assessing quality of care but may be influenced by patient factors. We investigated how currently endorsed performance measures for glycemic control in diabetes may be influenced by case mix composition. We assessed differences in A1C performance measure threshold attainment by case mix factors for A1C >9% and examined how lowering the threshold to A...

This study was conducted with the development of instant fish soup mix and finding out the effect of fish powder on it. Ingredients of soup mix were cooked and dried up to desired moisture content. The drying or dehydration was done by using a mechanical dryer (Cabinet dryer) at constant air flow rate and constant temperature with varying thicknesses. After drying the dried products were ground...

BACKGROUND We undertook a randomised, double-blinded, placebo-controlled, crossover trial to test whether intake of artificial food colour and additives (AFCA) affected childhood behaviour. METHODS 153 3-year-old and 144 8/9-year-old children were included in the study. The challenge drink contained sodium benzoate and one of two AFCA mixes (A or B) or a placebo mix. The main outcome measure ...

Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...